Diagnostic accuracy of MR planimetry in clinically unclassifiable parkinsonism

نویسندگان

چکیده

IntroductionQuantitative MR planimetric measurements were reported to discriminate between progressive supranuclear palsy (PSP) and non-PSP parkinsonism, yet few data exist on the usefulness of these markers in early disease stages.MethodsThe pons-to-midbrain area ratio (P/M) Magnetic Resonance Parkinsonism Index (MRPI) as well new indices, termed P/M2.0 MRPI2.0, multiplying former by a third ventricle (3rdV) width/frontal horns (FH) width, calculated T1-weighted images 84 patients with clinically unclassifiable neurodegenerative parkinsonism (CUP) at time imaging. Areas under curve (AUCs) for predicting future PSP was determined. The final clinical diagnosis made after least 24 months follow-up.ResultsFinal Parkinson's 55 patients, multiple system atrophy 12 cases, 17. At baseline imaging, had significantly higher MRPI, P/M, MRPI2.0 values compared other groups. AUCs discriminating 0.91 both P/M MRPI 0.98 MRPI2.0.ConclusionsBrainstem-derived measures yield high diagnostic accuracy separating from stages when criteria are not fully met. Consistent underlying pathology PSP, our study suggests that inclusion 3rdV width makes more accurate diagnosing stage than MRPI.

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ژورنال

عنوان ژورنال: Parkinsonism & Related Disorders

سال: 2021

ISSN: ['1353-8020', '1873-5126']

DOI: https://doi.org/10.1016/j.parkreldis.2020.11.019